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Session: Cultivating Carotenoid Insights in Foods, Model Systems, and Humans (Poster Theater Flash Session 2)

(PTFS02-02-24) Gut Microbial Composition, but Not Diversity, Changed With High-Astaxanthin Salmon Consumption in Obese, Prediabetic Individuals

Saturday, June 29, 2024
5:04 PM – 5:08 PM CT
Location:  W185A-C

    Presenting Author(s)

  • Gabrielle Glime, MA, CLC

    Clinical Research Associate
    University of Colorado Anschutz Medical Campus
    Aurora, Colorado, United States

    Disclosure(s): No relevant financial relationship(s) with ineligible companies to disclose.

    • Co-Author(s)

  • DF

    Daniel N. Frank, PhD

    University of Colorado Anschutz Medical Campus
    Aurora, Colorado, United States

  • LB

    Lillian Berman

    University of Colorado Denver-Anschutz Medical Campus

  • Nancy F. Krebs, MD, MS (she/her/hers)

    Professor of Pediatrics, Head, Section of Nutrition
    University of Colorado Anschutz Medical Campus
    Aurora, Colorado, United States

  • DL

    Dingbo Lin, PhD

    Associate Professor
    Oklahoma State University
    Stillwater, Oklahoma, United States

  • Minghua Tang, PhD

    Associate Professor
    University of Colorado Anschutz Medical Campus
    Aurora, Colorado, United States

Objectives: To determine the effect of salmon consumption with different astaxanthin content (wild caught vs. farmed) on gut microbiota in adults with obesity and pre-diabetes.

Methods: Adults with obesity and prediabetes participated in a randomized, cross-over study. The two interventions were consumption of wild caught or farmed salmon consumed at one serving (3 oz) per day (provided). Each intervention was 4 weeks long and the washout duration between the two interventions was 12 weeks. Another 5-week washout was included prior to participants beginning their first intervention. Except for the salmon provided, participants were advised to avoid seafoods that were high in astaxanthin during the intervention and washout. Participants filled out a daily intake log to record actual salmon intakes. Stool samples were collected at the beginning and end of each dietary intervention period. 16S rRNA sequencing was conducted on all stool samples.

Results: Thirty-one participants completed the study (n=9 male, n=19 female, n=2 not reported) with 74% Caucasian and 68% identified as non-Hispanic. The average age and BMI were 43±11.5 y and 30.3±4.3 kg/m2, respectively. Overall, participants consumed 80% of prescribed salmon and compliance did not differ between the farmed vs. wild-caught interventions. Consuming farmed salmon did not change gut microbial composition or diversity over time. When consuming wild caught salmon, no effect of time was observed on alpha diversity but a nominaleffect of time was detected on gut microbial composition (P=0.04). Specifically, the abundance of Eggerthellaceae, which may have potential anti-inflammatory effects, increased over time.

Conclusions: Salmon with a high-astaxanthin content (wild-caught) appeared to promote the growth of Eggerthellaceae within 4 weeks of consumption, suggesting its potential anti-inflammatory effects in adults with obesity and prediabetes via a feasible diet change.

Funding Sources: USDA NIFA, Colorado Clinical and Translational Sciences Institute (CCTSI)