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Session: Nutrient Status and Supplementation in Life's Beginnings (Oral 30)

(OR30-01-24) Association of Maternal Zinc Intake With Hypertensive Disorders of Pregnancy: The nuMoM2b Study

Monday, July 1, 2024
4:00 PM – 4:12 PM CT
Location:  W375A

    Presenting Author(s)

  • LL

    Liping Lu, MD, PhD

    Assistant Professor
    Ball State University
    Muncie, Indiana, United States

    Disclosure(s): No relevant financial relationship(s) with ineligible companies to disclose.

    • Co-Author(s)

  • YZ

    Yijia Zhang

    Columbia University, United States

  • MA

    Meghan Angley

    Columbia University, United States

  • UR

    Uma Reddy

    Columbia University, United States

  • AF

    Alyce D. Fly, PhD

    Professor and Chair, Nutrition and Health Science
    Ball State University
    Muncie, Indiana, United States

  • KK

    Ka Kahe, MD, ScD

    Professor
    Columbia University
    New York, New York, United States

Objectives: Laboratory studies suggest that zinc may be involved in blood pressure regulation and in the pathogenesis of hypertension. We aimed to investigate preconception maternal zinc intake in relation to the risk of hypertensive disorders during pregnancy (HDP).

Methods: A secondary analysis was conducted using data from the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-To-Be (nuMoM2b) (n=10,038). A total of 7,737 participants with available data and without chronic hypertension were included in the analysis. Information on diet in the three months before pregnancy was collected using the modified Block 2005 Food Frequency Questionnaire. Zinc intake was derived from dietary and supplemental sources. Blood pressure and HDP were assessed in the clinical visits during pregnancy. The associations of interest were estimated by multivariable-adjusted logistic regression models.

Results: After controlling for potential confounders including age, race, marital status, BMI, insurance, education, sex of the baby, conception season, poverty, smoking, prenatal vitamin use, and a few other dietary variables, zinc intake was inversely associated with HDP. The adjusted odds ratio (OR) and 95% confidence interval (CI) across quartiles of energy density-adjusted zinc intake were 1.00, 0.70 (0.57-0.85), 0.69 (0.53-0.89) and 0.71 (0.53-0.96), p for trend=0.27.

Conclusions: Data from this large cohort of US nulliparous women indicate an inverse association between preconceptional maternal zinc intake and hypertensive disorders of pregnancy.

Funding Sources: Faculty start-up funds from Department of Nutrition and Health Science, College of Health, Ball State University