Community and Public Health Nutrition (Poster Session)
(P20-014-24) Effectiveness of a 10-Wk Lifestyle-Change Protocol With Counseled Dietary Adequacy on the Oxidative Stress of Adults With NCD-Lipoglucotoxicity
Objectives: The survey of our 28-yr long dynamic cohort study “Move for Health” showed non-communicable chronic diseases (NCDs) with lipodystrophy and muscle-atrophy characteristics underlied by mechanisms of metabolic stress associated with behavioral factors. In that case, our 10-wk lifestyle protocol with supervised physical exercises and counseled dietary adequacy (LiSM) has proved highly effective in overcome physical inactivity and unfitness (aerobic and strength) and reducing these metabolic stress-underlying diseases. The aim now is to evaluate the dietary-related responses of 10-wk LiSM intervention on oxidative stress-associated NCDs.
Methods: From the baseline of 1,171 participants of our dynamic cohort study (2005 to 2019) half continued to a 10-wk longitudinal intervention with LiSM including supervised mixed (endurance and resistance) exercises and dietary counseling. Both moments were used for assessments of dietary intake (HEI calculation), body composition and plasma biochemistry. Fasting plasma was used also for analysis of pro-oxidant (MDA, GSSG and Hcy) and anti-oxidant (GSH, Cys, carotenoids, alpha-tocopherol and Total Anti-oxidant Performance- TAP). Statistical comparisons (Mo-M1) were undertaken for p=0.05.
Results: The 91.7% inadequacy of HEI (less than 100 points) and higher ultra-processed foods (53.9% CHO/Fiber and 40.3% Na/K) were significantly attenuated by 10-wk LiSM either in continuous or categorized variables. Along with the dietary improvements there was also an increased plasma anti-oxidant level: GSH, Cys, beta-carotene and TAP, as well as the plasma reductions of pro-oxidant levels of MDA, GSSG and Hcy. These led to significant reductions in P90 pro-oxidant and increases in P10 anti-oxidant markers. In parallel to anti-oxidant improvement, the 10-wk LiSM led to significant reductons of the prevalence of studied NCDs.
Conclusions: The 10-wk LiSM of the “Move for Health” study presented evident effectiveness towards NCDs reduction by restoring antioxidant defenses and attenuating metabolic stress.
