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Protocols (Poster Session)

(P30-011-24) Features of Dietary Protocols for Assessing Salt-Sensitivity of Blood Pressure in an Outpatient Setting: A Systematic Review Protocol

Monday, July 1, 2024
11:45 AM – 12:45 PM CT
Location: Poster Board 10
Disclosure(s):
Madha Rani Das, BS: No relevant financial relationship(s) with ineligible companies to disclose.


Objectives: Salt-sensitivity of blood pressure (SSBP) is an independent risk factor for cardiovascular disease and determines the effectiveness of dietary interventions to lower blood pressure in those with hypertension. The outpatient dietary protocol has been suggested as the reference method to characterize salt sensitivity (SS) due to its reproducibility and prediction of cardiovascular risk; however, there is a lack of standardization of methods and inconsistencies in the reporting of diet protocols in the literature. Thus, this review aims to systematically synthesize the literature on the methodological approaches and dietary protocol features used to characterize SS to guide study protocol development.

Methods: The protocol was developed following the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA-P) guidelines. The electronic databases MEDLINE-PubMed, CINAHL and Cochrane Library will be searched for relevant literature using pre-defined terms. Studies will be eligible for inclusion if they use the outpatient dietary protocol to assess SS in adults in free-living populations. The review will be conducted using the Covidence platform. Two authors will individually screen titles, abstracts, and relevant full texts to determine eligibility. Data will be extracted for features of the reference protocol including prescription and characterization diets, treatment order, sodium and potassium content, cutoff values for classifying salt sensitivity, procedure and device used for blood pressure readings, and dietary compliance.

Results: N/A (study protocol)

Conclusions: The results of this review can be used to guide study protocol development for assessing salt-sensitivity of blood pressure in an outpatient setting.

Funding Sources: This project is supported by the USDA National Institute of Food and Agriculture, Hatch/Multistate Project 1021322 (WVU00725).