(P15-015-24) Single Centre Observational Study of Regular Consumption of Low Caloric High Protein Homemade Meals Alongside Weight Loss Medicines on Metabolic Profile in Patients With MS
AMC MET Medical College and Research Centre Ahmedabad, Gujarat, India
Objectives: To evaluate impact of regular consumption of low caloric high protein homemade meals alongside weight loss medicines on metabolic profile of patients with MS.
The prevalence of MS has increased exponentially in last two decades and more so after COVID pandemics alongside numerous weight loss interventions with both favourable and adverse health outcomes. India is a capital of patients with metabolic syndrome occurring at a quite young age due to altered body composition with inflammations going on at the backstage. Various studies had already documented low to very low consumption of protein and micronutrients across many parts of world including India and to overcome this we designed a strategy to supplement them alongside standard of care medical and lifestyle intervention for MS.
Methods: Adults aged more than 18’th birthday were screened and diagnosed as a patient of MS according to WHO criteria. On enrolment brief history about trajectories of weight changes and intercurrent medical illnesses since birth including medications schedules, medical/surgical interventions and attempts to lose weight with and without any benefits/hazards were noted down. Anthropometric indices including height, weight, BMI and waist/Hip ratio, general medical and physical check-up including BP Pulse-oximetry and systemic examinations were performed and noted down. Acanthosis nigricans was the most common visible identifications. All participants underwent 3 samples OGTT with insulin levels in all 3 samples alongside many other biochemistry tests in a NABL accredited laboratory.
Results: There were significant reductions in metabolic profiles including Lipid profile, HS CRP, hepatic transaminases and glycaemic parameters across wide range of metabolic derangements. Amongst patients with dyslipidaemia there were significant reductions in triglycerides and borderline elevations in HDL. In diabetic and prediabetic patients there were significant reductions in FBS, PPBS and glycaemic parameters like HBA1C. Many participants with prediabetes and diabetes had improvement in fibromyalgia, lethargy and lassitude.
Conclusions: Efforts are needed to raise awareness of the impact of life-style educations on metabolic complications including MS, DM and CVD.
