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Kymberly Gowdy, PhD (she/her/hers)

Associate Professor, Division of Pulmonary, Critical Care and Sleep Medicine
Ohio State University
Columbus, Ohio, United States

I am currently an Associate Professor of Internal Medicine at the Ohio State University (OSU) and the Associate Director of the Medical Scientist Training Program at the College of Medicine at OSU. My laboratory studies the impacts of environmental pollutants on the pulmonary immune responses, with an emphasis on defining novel mechanisms behind how air pollutants alter the pulmonary host defense response and lipid metabolism. This research interest started during my doctoral studies and has continued throughout my career. As evident from my list of publications, ongoing funding through the NIEHS, and strong collaborations with other NIEHS-funded investigators, the central hypothesis of my research program is that air pollutants target pulmonary lipid metabolism with detrimental consequences for the clearance of pathogens and apoptotic cells. My laboratory utilizes rodent pollution exposure models (ozone and concentrated ambient particulate matter), clinically relevant pulmonary infections coupled with flow cytometry, fluorescent-activated cell sorting (FACS) of immune cells, and mass spectrometry based lipidomics to investigate the macrophage phenotypes and function in the lung during inflammation. Additionally, we translate our findings in human samples collected from individuals that have undergone controlled laboratory air pollution exposures.

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