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Session: Dietary Patterns for Human Health (Poster Theater Flash Session 12)

(PTFS12-02-24) Having Takeaway or Delivery Meal Was Associated With Higher Risk of Liver Steatosis: A Prospective Analysis

Monday, July 1, 2024
8:04 AM – 8:08 AM CT
Location:  Hall F1 (The Hub) - Poster Theater

    Presenting Author(s)

  • Xinyuan Zhang, PhD

    Postdoctoral Fellow
    Brigham and Women's Hospital and Harvard Medical School
    Boston, Massachusetts, United States

    Disclosure(s): No relevant financial relationship(s) with ineligible companies to disclose.

    • Co-Author(s)

  • Longgang Zhao, PhD (he/him/his)

    Postdoctoral associate
    Yale School of Nursing
    Orange, Connecticut, United States

  • XZ

    Xuehong Zhang, MD, ScD

    Brigham and Women’s Hospital and Harvard Medical School
    Boston, Massachusetts, United States

Objectives: Metabolic dysfunction-associated fatty liver disease (MASLD) and takeaway or delivery meal have both become increasingly common, but no study has examined their potential associations.

Methods: Data were obtained from the UK Biobank (project #87303). At baseline 2009–2010, participants answered the yes/no questions of their past 24-hr meal type: takeaway/delivery meal, restaurant meal, sandwiches from shops, ready prepared meal, or home cooked meal. Incident MASLD was defined by in-hospital medical records. Participants with a history of MASLD and missing covariates (age, sex, socioeconomic status, smoking status, alcohol intake, physical activity, body mass index, and total energy intake) were excluded in Cox proportional hazards regression of each meal type and incident MASLD. In a subset of participants, between 2014–2015, multi-echo spoiled-gradient-echo acquisition was used to calculate the liver steatosis level using the proton density fat fraction (PDFF). In the secondary analysis, logistic regression was used to analyze the imaging-proven steatosis, defined as PDFF ≥5%, adjusting for the same set of covariates.

Results: Among 55,492 participants in the primary analysis, during the follow-up, 483 MASLD was documented. Having takeaway/delivery meal was associated with a significantly higher risk of developing MASLD (adjusted hazard ratio=1.50; 95% CI: 1.03-2.17; P=0.03; comparing yes to no). Among 5121 participants in the secondary analysis, 1395 had imaging-proven steatosis. Having takeaway/delivery meal was also associated with a significantly higher risk of steatosis indicated by high PDFF (adjusted odds ratio=1.43; 95% CI: 1.07-1.92; P=0.02).

Conclusions: These preliminary prospective results suggest that takeaway or delivery meal was associated with a higher risk of steatotic liver disease, as suggested by both liver imaging marker and clinical diagnosis, although the single 24-hr recall may not represent the long-term dietary habit.

Funding Sources: National Cancer Institute