Skip to main content
NUTRITION 2024 Main banner
Icon Legend
This session is not in your schedule.
This session is in your schedule. Click again to remove it.
Back

Session: Dietary Manipulation to Support Exercise Performance (Poster Theater Flash Session 20)

(PTFS20-04-24) Post Exercise Increases in Erythropoietin Occur Independent of Consuming a Ketone Monoester Supplement Plus Carbohydrate or Carbohydrate Alone Before Aerobic Exercise

Monday, July 1, 2024
4:12 PM – 4:16 PM CT
Location:  Hall F1 (The Hub) - Poster Theater

    Presenting Author(s)

  • Jillian T. Allen, MS RDN

    Research Dietitian
    US Army Research Institute of Environmental Medicine
    Natick, Massachusetts, United States

    Disclosure(s): No relevant financial relationship(s) with ineligible companies to disclose.

    • Co-Author(s)

  • EH

    Emily E. Howard, PhD

    Nutrition Physiologist
    US Army Research Institute of Environmental Medicine
    Natick, Massachusetts, United States

  • JM

    Julie McNiff

    Combat Feeding Directorate, United States

  • LM

    Lee M. Margolis, PhD, RD

    U.S. Army Research Institute of Environmental Medicine

Objectives: Ketone monoester supplementation during the recovery phase of aerobic exercise has been reported to increase blood erythropoietin (EPO) concentrations. Whether consuming a ketone monoester supplement before aerobic exercise impacts post-exercise EPO concentrations is undetermined. The objective of this study was to examine the effect of ketone ester plus carbohydrate (KE+CHO) supplementation on the change in EPO concentrations during a 4-mile bout of load carriage exercise, compared with carbohydrate (CHO) alone.

Methods: Using a randomized, double blind crossover design, twelve men consumed KE+CHO (573 mg KE/kg body mass, 110 g glucose) or CHO (110 g glucose) 30 minutes before a 4-mile bout of self-paced treadmill exercise (KE+CHO:51±13%, CHO: 52±12% V̇O2peak) wearing a weighted vest equal to 30% of their body mass (25±3 kg). Blood samples for analysis were obtained under resting fasted conditions before (PRE) consuming the KE+CHO or CHO supplement alone and immediately after exercise (POST). Mixed model ANOVA was used to assess the effects of treatment, time, and their interaction on blood analytes.

Results: Change (∆) is shown as POST minus PRE. ∆βHB was higher (P < 0.05) in KE+CHO compared with CHO (2.5 ± 0.8 vs. 0.0±0.1 mM). ∆Glucose (5.1 ± 17.8 vs. 30.8 ± 26.8 mg/dL) and ∆glycerol (0.6 ± 2.2 vs. 4.3 ± 4.6 mg/L) were lower (P < 0.05) in KE+CHO compared with CHO. ∆Insulin (13.3 ± 6.2 vs. 10.7 ± 8.3 uIU/mL) and ∆lactate (2.3 ± 1.8 vs. 2.4 ± 1.9 mM) were not different (P > 0.05) between KE+CHO compared with CHO. There was no difference (P > 0.05) in ∆EPO (0.7 ± 2.9 vs. 1.46 ± 2.0 IU/L) between KE+CHO compared with CHO.

Conclusions: These data indicate that increased EPO post exercise is not influenced by increased beta-hydroxybutyrate concentrations when consuming a KE+CHO supplement before aerobic exercise compared with consuming CHO alone.

Funding Sources: Military Operational Medicine Research Program (MOMRP)

Disclaimer: Authors’ views do not reflect official DoD or Army policy.