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Session: Dietary Patterns and Components in Cancer Risk and Survivorship (Poster Theater Flash Session 6)

(PTFS06-05-24) Rising Rates of Kidney Cancer in the United States: Variation Among States and the Relationship to Obesity, Hypertension, and Smoking

Sunday, June 30, 2024

12:16 PM – 12:20 PM CT

Location: W185A-C

Presenting Author(s)

SW

Shihua Wang, MD, PhD

Research Specialist
The Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States

Disclosure(s): No relevant financial relationship(s) with ineligible companies to disclose.

Co-Author(s)

EG

Elizabeth M. Grainger, PhD, RDN (she/her/hers)

Research Dietitian
The Ohio State University
Columbus, Ohio, United States
MW

Maxine Z. Webb, MCR, RDN, CCRP (she/her/hers)

Clinical Research Dietitian
The Ohio State University, Ohio, United States
JP

Jason M. Prosek, MD

The Ohio State University College of Medicine, United States
FT

Fred K. Tabung, PhD, MSPH

Assistant Professor
Ohio State University
Columbus, Ohio, United States
AP

Anil Parwani, MD, PhD, MBA

The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute; The Ohio State University College of Medicine, Department of Pathology, United States
Steven K. Clinton, MD, PhD

Professor of Medical Oncology and Internal Medicine
The Ohio State University Wexner Medical Center
Dublin, Ohio, United States

Objectives: In the United States (US), renal cell carcinoma (RCC) is the 6th and 9^th most common malignancy in men and women, respectively, and represents a compendium of several histopathologic subtypes. We describe the variation in the incidence of RCC subtypes among states over time and its relationship to demographics and the prevalence of obesity, hypertension, and smoking between states.

Methods: Age adjusted incidence rates (AAIR) for RCC in individual states during 2001-2019 were acquired from the Surveillance, Epidemiology and End Results Program (SEER) Database. The prevalence of obesity and current smoking (1991-2019), and hypertension (1991-2019) was obtained from the Behavioral Risk Factor Surveillance System (BRFSS). All data were aggregated at the state level. The correlation between AAIR for RCC subtypes and the prevalence of risk factors in individual states was determined by linear regression.

Results: During 2001-2019 the AAIR for RCC increased by 32% with a male:female rate ratio of 1.7. Black males experienced a higher incidence than whites, while Asian/Pacific Islanders showed a significantly lower risk. In 2019 the AAIR among states varied by 1.8-fold from a low of 18.2 (Massachusetts) to a high of 32.4 (Louisiana). During this interval, the prevalence of obesity and hypertension continuously increased, while current smoking displayed a decreasing trend in both males and females. Linear regression analysis shows that the prevalence of obesity, current smoking, and hypertension in 2007-2009 in individual states are each significantly associated with the future incidence of RCC in 2017-2019.

Conclusions: RCC incidence varies significantly among states in the US, and is strongly associated with the prevalence of obesity, hypertension, and smoking. Efforts to control the critical risk factors of obesity and smoking while improving the management of hypertension are key to reducing the growing burden of RCC.

Funding Sources: Kidney Cancer Research Fund
Schoen Cancer Research Fund