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Late Breaking/Rapid Science Poster Session 1

(LB02-15-24) Dietary Polyamine Intake Lower the Risk of All-Cause and Cardiovascular Disease-Related Mortality: Korean National Health and Nutrition Examination Survey 2007–2015

Sunday, June 30, 2024
10:00 AM – 11:30 AM CT
Location: W185A-C - Poster Board 15

    Presenting Author(s)

  • JK

    Jieun Kim, PhD.

    Postdoctoral researcher
    Korea Institute of Oriental Medicine
    Daejeon, Taejon-jikhalsi, Republic of Korea

    • Co-Author(s)

  • YB

    Younghwa Baek

    Division of Korean Medicine Data, Korea Institute of Oriental Medicine, Republic of Korea

  • SL

    Siwoo Lee

    Division of Korean Medicine Data, Korea Institute of Oriental Medicine
    Daejeon, Republic of Korea

Disclosure(s):
Jieun Kim: No relevant financial relationship(s) with ineligible companies to disclose.


Objectives: To evaluate the relationship between dietary spermidine and spermine intake and all-cause and cardiovascular disease (CVD)-related mortality in a Korean population.

Methods: A total of 37,715 participants were included in a population-based cohort study. Dietary spermidine intake (µmol/d) was calculated using the average spermidine and spermine content (µmol/g) and daily consumed food components (mg/d) from 12 animal and plant food groups. Cox proportional hazards examined associations between dietary spermidine and all-cause and CVD-related mortality.

Results: Among the participants, 2,080 all-cause and 483 CVD-related deaths occurred. The lowest risk of all-cause and CVD-related mortality was found in the highest tertile of fruit, vegetables, legume, nut and seafood-derived spermidine and spermine intake, after adjusting for confounders. Furthermore, the relationship between dietary spermidine intake and all-cause and CVD-related mortality was more pronounced in men and older individuals than in their counterparts.

Conclusions: Higher intakes of fruit, vegetables, legume, nut and seafood-derived spermidine were associated with lower CVD-related and all-cause mortality in Korean adults.

Funding Sources: This work was supported by the Korea Institute of Oriental Medicine [grant number KSN1732121].