(P10-048-24) Prenatal Supervised Physical Activity Maintains Glycemic Patterns in Women With Obesity During Pregnancy

Objectives: To determine the effects of a physical activity (PA) intervention on longitudinal glucose data as captured via professional Continuous Glucose Monitoring [CGM] compared to standard of care (SOC). We hypothesized that new-onset PA during gestation will alter 24-h glycemic profiles in women with obesity compared to SOC women.

Methods: Participants enrolled in a randomized controlled trial (NCT02125149) assessing the effect of PA during pregnancy with obesity on maternal and offspring health outcomes could opt-in to participate in this ancillary study. Starting at gestational week 12, professional CGM sensors (FreeStyle Libre Pro, Abbott, USA) were worn for 14-days/trimester by overall healthy, pregnant women with obesity without existing PA regimens at baseline (N=18). At week 14, women were randomized to either PA (N=9), 3x/week of supervised 30-45min moderate intensity exercise, or SOC (N=9). CGM sensors recorded interstitial glucose values in 15-min intervals across the 14-day wear-time periods. CGM data obtained were processed using the ‘cgmanalysis’ and ‘iglu’ package in R version 4.3.1. Functional data analysis (FDA) ‘fda’, ‘fdapace’ was used to model glucose data over 24h by trimester within and across randomization groups.

Results: From the 24h glycemic profiles modeled at 12 weeks (Baseline), 24-hr glucose profiles trended downwards during the 2^nd and 3^rd trimester in SOC [p=0.21], with significantly lower temporal glycemia around 10am [p < 0.05] and 3pm [p < 0.05]. No 24h glycemic profile change from Baseline was detected in PA across subsequent trimesters [p=0.82]. Modeled 24h glycemic profiles were significantly lower in SOC compared to PA during the 2^nd and 3^rd trimester [p=0.04], specifically during late morning [9-11am, p< 0.05] and early afternoon [1-3pm, p< 0.05].

Conclusions: Data suggest that a moderate-intensity exercise intervention during pregnancy in previously non-active women with obesity manifests in 24h glycemic profile maintenance. Whether preservation of 24h glycemic profiles in this population affects offspring health remains to be elucidated.

Funding Sources: NCT02125149 is funded by USDA-ARS Project 6026-51000-012-06S, PI: Andres. This study was funded by NIGMS/NIH under Award Number P20GM109096 (ACRI, PI:Weber).