(P03-055-24) Association Between Anthropometrics or Diet and Adipokines After Myocardial Infarction: An Analysis of Baseline Data From the DICA-NUTS Trial

Objectives: Diet is a foundational component of secondary cardiovascular disease prevention and may influence adipokines. Our aim was to investigate associations between anthropometrics and diet with circulating adipokines among patients after a recent myocardial infarction (MI). We hypothesized that excess adiposity and unbalanced nutrient intake would be associated with higher levels of proinflammatory adipokines.

Methods: A cross-sectional analysis was performed using baseline data from the multicenter DICA-NUTS (DIeta CArdioprotetora Brasileira
supplemented with nuts) clinical trial of Brazilians 2 to 6 months post-MI. Anthropometric measures included body mass, BMI, waist circumference (WC), and waist-to-hip ratio (WHR). The adipokines measured were leptin, resistin, progranulin and adiponectin from plasma samples using enzyme-linked immunosorbent assay. Diet was assessed by a single 24-hour (24hr) recall collected by a dietitian. Nutrients were calculated with Sistema Vivanda de Alimentação software which prioritizes Brazilian nutrition composition tables. Association between baseline adipokines and anthropometrics or nutrients were determined by Spearman correlation coefficients.

Results: 1163 participants were included in the analysis (75% men, 68% white, 58±9 y) with an average of 110 d (SD±37) post-MI. Participant anthropometrics were: BMI 28.5±4.3 kg/m², WC 98±11 cm, WHR 0.97±0.1 and adipokines means were: adiponectin 526±31 ng/mL, resistin 1895±231 pg/mL, leptin 3555±1587 pg/mL, progranulin 4123±303 pg/mL. Age was positively associated with progranulin concentrations (r=0.17, p=0.03). Leptin concentrations were inversely associated with consumption of trans fatty acids (TFA) (r=-0.16, p=0.03; mean intake 0.04±0.04 g). Consumption of cholesterol (mean 292±238 mg) was inversely associated with progranulin (r=-0.23, p=0.003) and leptin (r=-0.20, p=0.01) concentrations. No significant associations between adipokines and anthropometrics or other nutrients were found.

Conclusions: Following a recent MI, TFA and cholesterol intakes were weakly and inversely associated with adipokines whereas measures of adiposity showed no associations. These findings suggest that diet influences the adipocyte inflammatory profile post MI.

Funding Sources: Hcor, PROADI-SUS and Brazilian Ministry of Health