(P03-056-24) Association Between Nutritional Status, Nutrient Intakes, and Survival in Lung Cancer Patients Undergoing Chemotherapy

Objectives: Malnutrition is associated with a greater risk of morbidity and mortality. This study was conducted to investigate the association between nutritional status, nutrient intakes, and survival in lung cancer patients undergoing chemotherapy.

Methods: Among 164 lung cancer patients who participated in the randomized phase II study pf platinum-based chemotherapy, 145 lung cancer patients who completed a 24-h dietary recall were selected. The nutritional status of each subject was assessed using the Patient Generated-Subjective Global Assessment (PG-SGA) tool. The chi-square test and generalized linear regression analysis were used to compare the distribution of subjects and mean differences according to nutritional status, respectively. Long term survival was plotted according to the Kaplan Meier method.

Results: A high proportion of patients (48 of 145, 33%) were classed as having poor nutritional status. The overall survival was 13.6 months ± 10.0(standard error). The malnourished patients had a lower exercise (p=0.0002), Body mass Index (p < 0.0001), and overall survival than those with well-nourished, whereas ECOG(Eastern Cooperative Oncology Group, p=0.0007) and PG-SGA score(p < 0.0001) were significantly higher in malnourished patients than those with well-nourished. Intake of total energy and carbohydrate was significantly lower (p < 0.0001) in malnourished patients than those with well-nourished. The intake of total food group (p < 0.0001), grains and their group (p=0.0006), vegetables (p=0.0045), and meats and their group (p=0.0292) were significantly lower in malnourished patients than those with well-nourished. A comparison of the survival curves by Kaplan-Meier analysis showed a significantly lower overall survival in malnourished lung cancer patients than those with well-nourished (p=0.0029).

Conclusions: The results show that the malnourished lung cancer patients are lower nutrient intakes and overall survival than those with well-nourished. Further studies are needed to confirm these findings and to explore the potential benefit of nutritional status and nutrient intakes to increase overall survival.

Funding Sources: The study was supported by the National Cancer Center(Grant numbers 1410660, 1910281, and 1610330).