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Dietary Bioactive Components (Poster Session)

(P04-043-24) Soy Protein Concentrate Diets Reduce Liver Lipopolysaccharide-Binding Protein Expression and Liver Inflammation in Obese Zucker Rats With Liver Steatosis

Sunday, June 30, 2024
12:45 PM – 1:45 PM CT
Location: Poster Board 116

    Presenting Author(s)

  • WL

    Wei Li, PhD

    Assistant Professor
    University of Arkansas for Medical Sciences
    Little Rock, Arkansas, United States

    • Co-Author(s)

  • RH

    Reza Hakkak, PhD

    Professor
    University of Arkansas for Medical Sciences
    Little Rock, Arkansas, United States

Disclosure(s):
Wei Li, PhD: No relevant financial relationship(s) with ineligible companies to disclose.
Reza Hakkak, PhD: No relevant financial relationship(s) with ineligible companies to disclose.


Objectives: To investigate the effect of soy protein concentrate (SPC) diet with low or high isoflavone (LIF or HIF) on lipopolysaccharide (LPS) translocation and liver inflammation in obese Zucker rats with liver steatosis.

Methods: A total of 21 six-week-old male obese (fa/fa) Zucker rats were given a control diet with casein as protein source (CAS) for 8 weeks to induce liver steatosis. Rats were then randomly assigned to CAS, SPC-LIF, or SPC-HIF (7 rats/group) diet for another 10 weeks. The expression of LPS-translocation and inflammation markers were quantified by qPCR in the liver and visceral adipose tissue (VAT).

Results: SPC-LIF and SPC-HIF diets significantly decreased liver LPS-binding protein (LBP) expression compared to CAS diet (p < 0.001 and p < 0.05, respectively). SPC-HIF diet also significantly decreased liver MCP-1 and TNF-α expression (p < 0.05) and had a trend to decrease liver iNOS expression (p = 0.06). SPC-LIF diet had a trend of reducing liver TNF- expression (p = 0.09) compared to CAS diet. In contrast, SPC diets did not affect the expression of LBP or inflammation markers (i.e. TNF-α and iNOS) in VAT.

Conclusions: SPC reduces liver inflammation in obese Zucker rats with developed liver steatosis, likely by inhibiting LPS translocation.

Funding Sources: This project was supported by USDA grant number 2020-67017-30841 to RH and a UAMS College of Health Professions seed grant to WL.