(P13-005-24) Association of Vegetable Intake and Severity of Pemphigus vulgaris: A Cross-Sectional Study

Objectives: Limited evidences on the association between dietary intake of vegetables and the severity of pemphigus vulgaris (PV) are available. This cross-sectional study aimed to investigate the relationship between vegetables intake and the severity of Pemphigus vulgaris disease.

Methods: A total of 138 pemphigus vulgaris cases were studied, of which 108 had pemphigus disease area index (PDAI) < 15, and 30 had PDAI >15. Dietary intakes were assessed using a valid 168-item food frequency questionnaire (FFQ) and the quartiles of dietary vegetables intakes were calculated.

Results: We found that individuals with the highest vegetables intake were 78% less likely to have increased PV severity compared with those with the lowest intake (OR: 0.22; 95% CI: 0.07–0.70). After adjusting for age, sex and energy intake, the association was still significant (OR: 0.20; 95% CI: 0.06–0.68). Taking energy intake did not change the association (OR: 0.20; 95% CI: 0.06–0.67). Further control for another potential confounder including corticosteroids use and physical activity revealed significant association between higher dietary vegetable intake and severity of PV disease (OR: 0.22; 95% CI: 0.06–0.81).

Conclusions: The evidence of our study shows that dietary vegetables intake is negatively associated with the severity of pemphigus vulgaris. Prospective cohort studies are needed to confirm these findings.

Funding Sources: No funding