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Nutritional Immunology and Inflammation/Immunometabolism (Poster Session)

(P14-021-24) Inadequacy Consumption of Immune Nutrients Is Associated With Type 2 Diabetes: The Mx – GDS Cohort Project

Sunday, June 30, 2024
12:45 PM – 1:45 PM CT
Location: Poster Board 490
Disclosure(s):
Abril I. Sánchez-Rosales, PhD.: No relevant financial relationship(s) with ineligible companies to disclose.


Objectives: Assess whether type 2 Diabetes is associated with lower nutrient inadequacy of some immune nutrients in a multicenter study.

Methods: We conducted a cross-sectional study. This multicenter study is embedded within the German Diabetes Study (GDS) and study population in Mexico from a Public Hospital (Medical Center “Adolfo López Mateos). The study is approved by the ethics committee of the University of Düsseldorf (4508), was registered at Clinicaltrials.gov (Identifier number: NCT01055093) and approved by the Ethics Committee of Universidad Autónoma del Estado de México (4851/2019E

Dietary collection was gathered using a validated semi-quantitative food frequency questionnaire. To determine insufficient intake based on sex and age. The estimated average requirements or adequate intake levels suggested by the National Institutes of Health were utilized as thresholds. Statistical analyses involved computing crude and multivariable-adjusted estimates using generalized estimated equations to accommodate intra-cluster correlation among consumption.

Results: We used baseline information of 711 participants enrolled in the Mx-Gr project between January 2009 and June 2022 (513 with diabetes and 198 without diabetes). Both in the crude models and in the models adjusted for age, sex, and IMC, presented diabetes is associated with a higher risk of vitamin E (O.R.: 2.06. C.I. 95%: 1.41 ; 3.00) and magnesium (O.R.: 1.58. C.I. 95%: 1.09 ; 2.30) deficiency. Mexican participants had a higher risk of inadequate consumption of vitamin A (O.R.: 2.18. C.I. 95%: 1.45 ; 3.28), Vitamin E (O.R.: 42.75. C.I. 95%: 18.9 ; 96.5) and magnesium (O.R.: 2.07. C.I. 95%: 1.37 ; 3.13), compared to German participants.

Conclusions: Several studies have indicated a correlation between insufficient intake of immune-boosting nutrients and the risk of developing type 2 diabetes. Our findings reinforce the significance of factors such as years of progression and dietary quality in this regard. Nutritional inadequacy of some nutrients (vitamin E and magnesium) considerate as immune nutrients are associated with type 2 diabetes.

Funding Sources: Funded by the German Federal Ministry of Health (Berlin, Germany). We thank Universidad Autónoma del Estado México / CONAHCYT.