(P14-018-24) Gut Microbiota Participates in Autoimmune and Metabolic inflammation:Liver Interplay

Objectives: This investigation aimed to analyse the differences and/or similarities between subjects with systemic lupus erythematosus (SLE), and metabolic inflammation (MI), concerning the potential mediating impact of microbiota on liver health in such conditions.

Methods: Anthropometric and biochemical measurements were obtained from 60 adult participants, and faecal samples were analysed using the 16S technique. Statistical analyses were conducted to evaluate differences in anthropometric, biochemical, inflammatory parameters and bacteria between individuals with SLE and those with MI. Additionally, a regression model was fitted to investigate linear associations with liver status.

Results: The analyses revealed significant differences in muscle mass, waist circumference, glucose, and triglycerides measurements between both inflammation types. Hepatic markers including ALT, GGT, FLI and LAP indices were more deteriorate in patients with MI. Additionally, the TyG index exhibited significant variation between the SLE and MI groups. Although alpha diversity did not show statistical significance, there was a difference in Bifidobacterium abundance between the two diseases (p=0.01). An interaction effect was observed between IL-6 levels and the Bifidobacterium genus, leading to a modification of the FLI index effect in both disease groups.

Conclusions: Current findings highly the intricate interplay between SLE, MI, and gut microbiota composition, particularly in hepatic markers. The interaction effect between IL-6 levels and the Bifidobacterium genus hints at a novel avenue for understanding the underlying mechanisms contributing to metabolic dysregulation in inflammatory conditions. These insights hold promise for modulating gut microbiota and mitigating inflammation, thereby advancing personalized strategies for managing complex inflammatory disorders and implementing precision nutrition interaction.

Funding Sources: This project has been supported by the Government of the Community of Madrid (Consejería de educación y Universidades) through the Regional Research and Innovation Support Program. Directorate General of Research and Technological Innovation (SINERGICOS 2020) (METAINFLAMACION-CM (ref. Y2020/BIO-6600).