(P15-043-24) Impact of Glucomannan, Inulin, and Psyllium Supplementation on Weight Loss in Adults With FTO, LEP, LEPR, and MC4R Polymorphisms: A Randomized, Placebo-Controlled Trial

Objectives: This study aims to determine the impact of a fiber supplement on body weight and composition in obese individuals with specific genetic polymorphisms.

Methods: It involved 112 obese adults, each with at least one minor allele in the FTO, LEP, LEPR, or MC4R polymorphisms. Participants were randomized to receive either a fiber supplement (glucomannan, inulin, and psyllium) or a placebo for 180 days.

Results: The experimental group showed significant reductions in body weight (treatment difference: -4.9%; 95% CI: -6.9% to -2.9%; p< 0.01) and BMI (treatment difference: -1.4 kg/m2; 95% CI: -1.7 to -1.2; p< 0.01) compared to placebo. Further significant decreases in fat mass (treatment difference: -13.0%; 95% CI: -14.4 to -11.7; p< 0.01) and visceral fat rating (treatment difference: -1.3; 95% CI: -1.6 to -1.0; p< 0.01) were noted. Homozygous minor allele carriers experienced greater decreases in body weight (treatment difference: -3.2%; 95% CI: -4.9% to -1.6%; p< 0.01) and BMI (treatment difference: -1.2 kg/m2; 95% CI: -2.0 to -0.4; p< 0.01), compared to heterozygous allele carriers. These carriers also had a more significant reduction in fat mass (treatment difference: -9.8%; 95% CI: -10.6 to -9.1; p< 0.01) and visceral fat rating (treatment difference: -0.9; 95% CI: -1.3 to -0.5; p< 0.01). A high incidence of gastrointestinal events was reported in the experimental group (74.6%), unlike the placebo group, which reported no side effects.

Conclusions: Dietary supplementation with glucomannan, inulin, and psyllium effectively promotes weight loss and improves body composition in obese individuals, particularly those with specific genetic polymorphisms.

Funding Sources: The authors declare that this study received funding from S.Lab (SOLOWAYS), LLC. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this abstract or the decision to submit it for publication.