(P04-021-24) Effect of Hemp Seeds on Lipid Profile of Overweight and Obese Adults From Querétaro, México

Objectives: The aim of this study was to evaluate the effect of hemp seeds on the lipid profile of overweight and obese adults from Querétaro, Mexico.

Methods: A total of 24 adults (18-40 years), male or female, with overweight or obesity (body fat >20% in men and >31.5% in women), and that signed the informed consent form, participated in a controlled, randomized trial. Lactating or pregnant women, individuals receiving pharmacological treatment for dyslipidemia, taking omega 3, niacin or plant based supplements (i.e. resveratrol) were excluded from the study The participants were randomly assigned to one of two of the following groups: 1. Hemp Seed (HS) group: received 14 g/d of peeled hemp seed; 2. Control group (CON): received no intervention. Both groups were followed for 10 weeks. A socioeconomic status questionnaire and a medical history were applied at the beginning of the study. Diet, anthropometric and body composition measurements, and blood lipid profile were done at the beginning and end of the study. A t-student test for independent samples and a paired t-student test were performed for between group analysis. The results were adjusted for confounding variables.

Results: No significant changes were observed in the concentration of cholesterol (HS: 1.78, CI: -1.5 to 5.06 mg/dL vs CON: 5.88, CI: 2.13 to 9.6 mg/dL; p=0.52), triglycerides (HS: 32.36, CI: 11.54 to 52.84 mg/dL vs CON: 12.41, CI: 0.49 to 24.28 mg/dL; p=0.43), LDL (HS: -6.18, CI: -11.02 to -1.29 mg/dL vs CON: 2.78, CI: 0.69 to 4.86 mg/dL; p=0.31), or HDL (HS: -1.65, CI: -2.76 to -0.53 mg/dL vs CON: -0.50, IC: -1.09 to 0.09 mg/dL; p=0.32). Similarly, no significant changes were observed between groups in atherogenic ratios, anthropometry or body composition measurements. The HS had a significant increase in calories (p=0.04) and carbohydrate intake (p=0.01), and lower protein intake (p=0.03) compared to the control group.

Conclusions: In the present study, intake of 14 g/d of hemp seed for 10 weeks did not modify the lipid profile of adults with overweight or obesity. More studies are necessary to evaluate the potential effect of hemp seed on cardiovascular risk.

Funding Sources: This study was partially funded by CONAHCYT.