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Global Nutrition (Poster Session)

(P24-017-24) Effect of Small-Quantity Lipid-Based Nutrient Supplements on Adolescent Physical Activity and Sedentary Behavior: A Follow-Up Study of iLiNS-DYAD Trial in Ghana

Monday, July 1, 2024
11:45 AM – 12:45 PM CT
Location: Poster Board 158
Disclosure(s):
Jonnatan Fajardo, MS RD: No relevant financial relationship(s) with ineligible companies to disclose.


Objectives: Previously, we found that children 4-6 y old who were exposed to small-quantity lipid-based nutrient supplements (SQ-LNS) during the first 1000 days had lower light physical activity (PA) and higher sedentary behavior (SB) compared to those not exposed to SQ-LNS. In this study, our objective was to investigate the long-term effect of pre- and post-natal SQ-LNS on PA and SB in 11-13 y old Ghanaian adolescents.

Methods: 1320 women (≤ 20 weeks gestation) were assigned to daily: iron and folic acid during pregnancy and placebo 0-6 mo postpartum (IFA), or multiple micronutrient capsule in both periods (MMN), or SQ-LNS in both periods (LNS); infants in the LNS group consumed SQ-LNS designed for children from 6-18 mo. We recruited a sub-sample of adolescents 11-13 y old for a 7-day PA assessment that included the self-report Physical Activity Questionnaire for Older Children (PAQ-C) and wrist-worn accelerometers (Actigraph wGT3x+) that measured PA and SB. We compared the SQ-LNS to non-SQ-LNS (IFA + MMN) groups using minimally adjusted ANCOVA models for the following outcomes: PAQ-C score, SB, vector magnitude counts per minute (VM cpm), and total minutes and percentage of time in light (LPA), moderate (MPA), vigorous (VPA), and moderate-to-vigorous PA (MVPA).

Results: 508 adolescents (55% female) completed the PAQ-C and 305 adolescents (58% female) provided accelerometer data with a mean wear time of 6.9 days. There were no significant differences in PAQ-C scores between the SQ-LNS and non-SQ-LNS groups: mean score of 2.5 vs 2.6, respectively. Additionally, the SQ-LNS and non-SQ-LNS groups did not differ in VM cpm (2884 vs 2977), percentage of time in LPA (25.9% vs 26.6%), MPA (6.2% vs 6.6%), VPA (0.4% vs 0.4%), or MVPA (6.6% vs 7.0%). Finally, there were no significant group differences in total minutes in LPA (2464 vs 2525), MPA (592 vs 628), VPA (35 vs 35), or MVPA (627 vs 664).

Conclusions: Adolescents who were exposed to pre- and post-natal SQ-LNS did not have higher levels of PA compared to adolescents not exposed to SQ-LNS. Despite differences at 4-6 yrs old, SQ-LNS may not have sustained long-term effects on PA and SB in adolescence.

Funding Sources:

Funding sources: NICHD & FID R01HD099811; Campbell Soup Company Nutrition Research Scholarship