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Dietary Bioactive Components (Poster Session)

(P04-056-24) Exploring the Association of Microbe-Containing Food Intake With Coronary Artery Calcification and Pericardial Adipose Tissue Volume

Sunday, June 30, 2024
11:45 AM – 12:45 PM CT
Location: Poster Board 129
Disclosure(s):
Aster Sigel: No relevant financial relationship(s) with ineligible companies to disclose.
Arpita Basu, PhD, MPH, RD: No relevant financial relationship(s) with ineligible companies to disclose.


Objectives: While microbe-containing food intake is hypothesized to yield positive health outcomes, its association with coronary artery calcification (CAC) and pericardial adipose tissue (PAT) remains unclear and warrants investigation. The objective of this study is to investigate whether microbe-containing food intake is associated with CAC and volume of PAT.

Methods: A cross-sectional analysis was conducted using baseline data from the Coronary Artery Calcification in Type 1 Diabetes study (n = 1159; T1D: n = 520; non-DM: n = 639). Participants completed a validated food frequency questionnaire (FFQ), underwent a physical examination, and had biochemical analyses. Measurements of CAC and PAT were obtained using electron beam computed tomography. FFQ data was categorized to three levels of daily intake of microbe–containing foods [low (Lo), < 104 CFU/g; medium (Med), 104-107 CFU/g; or high (Hi), >107 CFU/g]. We calculated percent daily food intake from each of the hi, med, low microbe-containing food categories to assess association of daily percent dietary microbe intake with CAC and PAT and their adjusted associations with selected physiological parameters. Associations between the percentage of microbe-containing food intake and the presence or absence of CAC (CAC Score > 0 vs. CAC = 0) were examined using logistic regression, and linear regression models were applied to evaluate PAT. Model 1 was adjusted for age, sex, and diabetes status. Model 2 included variables from Model 1, along with total calories, waist circumference, LDL, HDL, and systolic blood pressure.

Results: In the fully adjusted model, higher intake of microbe-containing foods was significantly associated with lower PAT volume [-0.219 (95% CI: -0.422, -0.016; P = 0.035)]. No significant association with the presence of CAC was found in either model.

Conclusions: There was a positive association between higher microbe-containing food intake and lower volumes of PAT. However, no significant association was detected with the presence of CAC, emphasizing complex relationships that warrant further investigation.

Funding Sources: American Diabetes Association