(P03-022-24) Grape Seed Extract Supplement With Nicotinamide, Vitamin C and Vitamin E Improved Skin Condition in Human

Objectives: Numerous studies have demonstrated that UV light and natural aging would cause the production of large number of free radicals in cells. Free radicals in skin cell could migrate to melanocytes and enhance the synthesis of melanin, making the skin dull; or disrupt the redox homeostasis, and causing the loss of collagen, resulting in skin water loss or the formation of wrinkles. Prior studies revealed that grape seed extract (GSE) contains abundant antioxidants, including proanthocyanin, catechin, quercitrin, tannin, and other polyphenols, which made GSE a highly effective active ingredient to suppress tyrosinase activity, hence lowering melanin synthesis. Besides, a previous clinical trial revealed that oral consumed nicotinamide could lessen the immunosuppressive effects induced by UV light. Therefore, our trial examined the skin-condition-improving effects including gloss, tone, color spots and other aspects of a combination of grape seed extract (GSE), nicotinamide, vitamin C, and vitamin E on Chinese female participants.

Methods: Effects of oral consumed GSE contained formula was investigated in a 56-day double-blind, randomized, placebo-controlled clinical trial involving 70 Chinese female participants on the improvement of skin conditions. Skin conditions were measured objectively by instruments including melanin, protoheme, skin gloss and tone, color spots, UV skin tolerance as well as skin texture, besides the physician evaluation and a self-assessment questionnaire.

Results: In compared to placebo group and baseline value on day 0, the GSE contained formula significantly reduced the levels of protoheme and melanin, improved the skin tone and gloss as well as faded dark spots after 28 and 56 days of therapy (p < 0.001). It suggested that GSE contained formula is effective in improving skin tone and color spots. In addition, after 56 days of treatment, the GSE contained formula reduced the minimum erythema dose (MED), assisting in the reduction of skin photosensitivity (p < 0.001).

Conclusions: Overall, these results showed that the GSE contained formula has the ability to improve women's skin conditions including skin gloss, skin tone, skin photosensitivity and color spots without causing any obvious negative consequences.

Funding Sources: Health and Happiness (H&H) China Limited