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Precision Nutrition/Nutrient-Gene (Poster Session)

(P29-002-24) Interaction Between FTO rs9939609 Polymorphism and Dietary Inflammatory Index (DII) Affect Prediabetes Risk in Indonesians

Monday, July 1, 2024
12:45 PM – 1:45 PM CT
Location: Poster Board 117
Disclosure(s):
Witri Ardini, Dr: No relevant financial relationship(s) with ineligible companies to disclose.


Objectives: Prediabetes, an intermediate stage between normoglycemic and diabetes, is a significant public health issue worldwide, including in Indonesia. Many factors contribute to the increased risk of prediabetes, including the interaction of genes and dietary intake. This study aims to examine the effect of the interaction between FTO rs9939609 polymorphism and dietary inflammatory index (DII), developed by Shivappa in 2014, on the risk of prediabetes in the Indonesian population.

Methods: A total of 569 participants, consisting of193 prediabetic and 376 healthy subjects aged 20-55 years), were recruited from four primary healthcare facilities in South Tangerang, Banten Province, Indonesia. Single Nucleotide Polymorphism (SNP) genotyping was done using the rhAmp SNP genotyping system. Dietary intake was assessed using a 24-hour dietary recall for three consecutive days. The DII was computed by assigning scores to 29 foods/nutrients. The DII score was then categorized into four quartiles, with the highest pro-inflammatory and the lowest anti-inflammatory values.

Results: Individuals with the A/A genotype have a 2.99 times higher risk of prediabetes (95% CI 1.43-6.27) than those with the T/T and T/A genotypes. There is an interaction between FTO rs9939609 and DII with a p-interaction of 0.087. Even if their intake is in the DII quartile 1-2 (relatively anti-inflammatory diet), those with the A/A genotype have a 3.06 times higher risk of prediabetes (95% CI 1.44-6.53) compared to the T/T and T/A genotypes. On the other hand, the risk of prediabetes for those with the T/T and T/A genotypes increases 1.64 times (95% CI 1.1-2.44) if their intake is in DII quartile 3-4 (relatively pro-inflammatory diet).

Conclusions: Our finding indicates that FTO rs9939609 polymorphism is associated with prediabetes risk and that the pro-inflammatory dietary intake has the potential to modulate it.

Funding Sources: This study was partially funded by the Institute for Research and Community Service (LP2M) of the State Islamic University (UIN) Syarif Hidayatullah Jakarta and the Ministry of Religion of the Republic of Indonesia.