(P10-088-24) Serum Vitamin D Concentrations and Associated Factors in Term and Preterm Newborns in Guadalajara, Mexico

Objectives: To evaluate serum vitamin D (VD) levels and associated factors in term and preterm newborns.

Methods: In a cross-sectional design, 95 mother-newborn dyads were included (80 term and 15 preterm) in a public hospital; newborns of any sex, with gestational age ≥ 30 weeks, without apparent malformations, were included with the consent of their mother. An interview was conducted with the mothers to request their authorization and to obtain personal, socioeconomic and pregnancy data; and the identification of risk factors for deficiency. The mother's weight and height were measured, and serum VD concentrations were determined in the mother and in newborns. Newborn´s weight, length, head circumference, tricipital and subscapular skin folds, and mid upper arm circumference were measured. Statistical analysis. Mothers and children with VD deficiency ( < 12 ng/mL) and insufficiency (12 to 20 ng/mL) were identified and potential risk variables identified. The serum VD concentration was compared between term and preterm newborns with the student's T test for two independent samples, and the correlation of the serum VD levels of the newborns with different variables was identified. The protocol was approved by the Hospital's Ethics and Research Committees.

Results: Mean age of the mothers was 25.4 ± 6.8 years; 23% with overweight and 19% with obesity. The frequency of VD deficiency in mothers was 3.2% and insufficiency in 35.8%, while in newborns was 3.4% and 18% respectively; without differences in serum VD concentrations between term and preterm newborns. No significant associations were identified between the VD concentrations of newborns with anthropometric variables and gestational age; a direct and significant correlation of the VD levels of the newborns with the mother's serum levels (r= 0.53; p< 0.001) and mother's age (r= 0.31; p< 0.001) was identified.

Conclusions: The majority of mothers and newborns of this population presented adequate levels of VD; the deficiency was unusual. The serum values of the newborns correlate with those of the mother, so an adequate nutritional status must be encouraged during pregnancy.

Funding Sources: Hospital Civil de Guadalajara "Dr. Juan I. Menchaca"