(P18-022-24) Evaluating the Efficacy of an Oral Skincare Supplement on Parameters of Skin Aging in Women and Men: Results From a 12-Week Randomized, Double-Blind, Placebo-Controlled Study

Objectives: To validate the efficacy of an oral skincare supplement on various parameters of skin aging, particularly crow’s feet wrinkles, skin smoothness, and skin hydration.

Methods: Healthy adults (26-64 years old) were recruited and randomly assigned in a double-blind fashion to the intervention group (n=31) or placebo group (n=32). The intervention group received an oral skincare supplement (HyaCera^TM), which contained 350 mg of wheat oil extract and 120 mg of sodium hyaluronate (Hyabest^Ⓡ(S)LF-P; Kewpie Corporation, Japan) in a nested capsule. The placebo capsules contained safflower oil and cellulose. Upon baseline assessment by a dermatologist, participants consumed one capsule per day for 12 weeks. Participants reported to the testing site for assessment at 4, 8, and 12 weeks. Assessments utilized both objective measurement devices and subjective questionnaires to quantify changes in skin condition and aging parameters.

Results: In the intervention group, daily supplementation for 8 weeks led to a significant reduction in crow’s feet wrinkles and improvement in facial and global skin smoothness from baseline compared to placebo, as measured by Visioscan® VC 98 (Courage and Khazaka, Germany) (p < 0.05). These improvements remained significant compared to placebo (p < 0.05) at week 12. Additionally, at week 12, the intervention group experienced significantly increased skin hydration and skin elasticity in the thigh region from baseline compared to placebo (p < 0.05), via Corneometer® CM 825 (Courage and Khazaka, Germany) and Cutometer® MPA 580 (Courage and Khazaka Electronic, Germany), respectively. Subjective questionnaire data revealed that compared to the placebo group at week 12, significantly more participants in the intervention group reported improvement in fine lines and wrinkles (p < 0.05), skin radiance/glow (p < 0.05), skin resilience/elasticity (p < 0.01), and general signs of aging (p < 0.05).

Conclusions: An oral skincare supplement improves crow’s feet wrinkles and skin smoothness as early as 8 weeks and may be considered as an effective supplement to ameliorate select signs of skin aging.

Funding Sources: The study was conducted by an independent contract research organization and funded and sponsored by Ritual (Natals, Inc.). Kewpie Corporation (Tokyo, Japan) also financially supported the study.