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Dietary Bioactive Components (Poster Session)

(P04-019-24) The Effect of Pro-Prebiotic Use on Biochemical Markers in Patients With Type 2 Diabetes

Sunday, June 30, 2024
11:45 AM – 12:45 PM CT
Location: Poster Board 96

    Presenting Author(s)

  • NE

    Nazan Erenoglu Son, Associate Professor

    Faculty of Health Sciences, Nutrition and Dietetics Department
    Anadolu University, Eskisehir, Turkey
    Tepebaşı, Eskisehir, Turkey

    • Co-Author(s)

  • ES

    Eren Son

    Eskisehir Osmangazi University, Turkey

Disclosure(s):
Nazan Erenoglu Son, Associate Professor: No relevant financial relationship(s) with ineligible companies to disclose.


Objectives: Type 2 diabetes mellitus (T2DM) is a chronic and comorbid disease that often occurs with increasing age and body weight. Medical nutrition therapy (MNT) plays an important role in DM and some nutritional supplements are recommended. In this study, we aimed to compare the biochemical parameters of patients with T2DM who received pro-prebiotics before, after and with the control group.

Methods: 150 patients with T2DM, aged 30-65 years, BMI 25≥ kg/m2, were given supplement capsules containing 500 mg of probiotics and 300 mg of prebiotics once daily for three months. The results of BMI, fasting blood glucose, creatinine, hematocrit, liver enzymes, triglycerides, LDL, uric acid, HBA1C, vitamin B12, blood pressure before and after the study were compared with the control group (n=85).

Results: As a result of the study, fasting blood glucose values of the patients before the study were found to be significantly lower than after the study and the control group (FBS before: 169.13±59.47, after: 153.64±35.91, p< 0.004). BMI, body weight and HBA1C (p < 0.006) values of the patients decreased at the end of the study compared to before. Vitamin B12 levels increased. However, no statistically significant difference was found.

Conclusions: The results of our study showed that probiotic and prebiotic supplementation in addition to routine MNT in diabetic patients may have positive effects on fasting blood glucose and indirectly on HBA1C in the long term. This pleasing result emphasizes the importance of probiotic and prebiotic supplements in achieving glycemic control in the treatment of T2DM. However, further studies are needed to answer the questions of which probiotics or prebiotics should be selected for supplementation or which foods and to what extent should clinicians recommend as probiotic or prebiotic sources in routine MNT.

Funding Sources: None