(P17-025-24) Effects of a Combined Magnesium and Vitamin D Supplementation in Individuals at Risk of Metabolic Syndrome: Secondary Analysis From the MagD Trial

Objectives: Poor vitamin D and Magnesium status are seen in Individuals with metabolic syndrome. Although higher serum concentrations of 25-hydroxyvitamin D (25OHD) are associated with better cardiometabolic health, results from vitamin D supplementation clinical trials on cardiometabolic outcomes are inconsistent. Magnesium is a cofactor for vitamin D metabolism, and therefore, we hypothesize that improving magnesium and vitamin D status concomitantly in those at risk of MetS may lead to greater improvements in cardiometabolic outcomes than vitamin D supplements alone. Our study aimed to determine the efficacy of a combined magnesium and vitamin D regimen compared to vitamin D only on raising s25OHD concentrations and on cardiometabolic outcomes in individuals at risk of MetS specifically with higher systolic blood pressure and waist circumference.

Methods: This is a secondary data analysis of a 12-week double-blinded controlled trial. Briefly, the parent study  had three treatment arms – magnesium + vitamin D (MagD) group, vitamin D only (VitD) group and a Placebo group. Participants in the MagD Group received 360 mg magnesium glycinate + 1000 IU vitamin D₃daily, VitD Group received 1000 IU vitamin D₃ daily, and Placebo Group received 10 mg of cellulose. Information on anthropometrics, dietary intakes, serum 25OHD, serum parathyroid hormone (PTH), serum inflammatory markers, and blood pressure were obtained.

Results: 95 overnight and obese participants completed the parent study. Participants did not exhibit metabolic syndrome i.e did not have 3 out of the 5 risk factors of MetS. In a subgroup of 23 participants with blood pressure >130mmHg, participants supplemented with Mg+D experienced the greatest increase in s25OHD of 10.5 ng/mL and decreases in blood pressure of -9.1 mmHg ( p< 0.05) compared to the D only group or the placebo. Additionally in a subgroup of 29 men and women with a waist circumference (WC) >35 cm in women and >40 cm in men, the Mg+D experienced the greatest increase in s25OHD of 5.4ng/mL although this was not associated with changed in WC.

Conclusions: A combined Magnesium and vitamin D supplementation may be effective in improving markers of MetS. Future studies should specifically investigate the combined impact of Mg and vitamin D  in at risk populations.

Funding Sources: Scientist Development Grant- American Heart Association to D Sukumar