(P27-011-24) Strain-Specific Therapeutic Potential of Lactiplantibacillus plantarum: A Systematic Review

Monday, July 1, 2024

11:45 AM – 12:45 PM CT

Location: Poster Board 359

Presenting Author(s)

Oranut Chatsirisakul

Undergraduate student
Chulalongkorn University
Bangkok, Krung Thep, Thailand

Co-Author(s)

YS

Yada Siripaopradit

Chulalongkorn University, Krung Thep, Thailand
CC

Chun-Wei Chang

National Taiwan University, College of Medicine, Taiwan (Republic of China)
PB

Patsakorn Buhngamongkol

Chulalongkorn University, Krung Thep, Thailand
Krit Pongpirul, MD, MPH, PhD (he/him/his)

Associate Professor
Chulalongkorn University
Bangkok, Krung Thep, Thailand

Disclosure(s):

Oranut Chatsirisakul: No relevant financial relationship(s) with ineligible companies to disclose.

Krit Pongpirul, MD, MPH, PhD: No relevant financial relationship(s) with ineligible companies to disclose.

Objectives: To systematically review the therapeutic potential and clinical benefits of Lactiplantibacillus plantarum strains on human health.

Methods: Adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and the PICO framework, a detailed search through PubMed and Embase databases identified relevant studies up to December 2023. The inclusion criteria were strictly followed, with study quality assessed via the Risk of Bias tools (ROB2).

Results: Analysis of 279 strains pinpointed 38 with significant mentions in human research. L. plantarum 299 emerged prominently in 12 studies, demonstrating a spectrum of benefits including gastrointestinal symptoms, infectious diseases, cancer, cardiovascular conditions, oral health, and iron deficiency. PS128 was central in 9 studies, enhancing psychological well-being; IS10506 in 7 studies, improving dermatological health; DR7 in 4 studies, enhancing cognitive functions; L-137 in 3 studies, bolstering immune responses; and dfa1 showcased in animal studies targeting obesity and liver health.

Conclusions: The therapeutic potential of L. plantarum is vast, with certain strains offering promising results for specific health concerns. Our findings advocate for the integration of these probiotics into clinical practice, guided by further investigation into their mechanisms, dosages, and long-term impacts.

Funding Sources: None