(P04-067-24) Impact of Brewer’s Spent Grain (BSG) and Bio-Transformed BSG Biscuits on Metabolic Health in Singapore Adults With Metabolic Impairments

Objectives: Brewers’ spent grain (BSG) is the main by-product of the beer-brewing industry, which is rich in dietary fiber, protein and antioxidant components. Bio-transformation of BSG with Rhizopus Oligosporus can enhance its nutrient value by increasing the content of soluble dietary fiber and releasing antioxidants. These nutrients may act as a prebiotic and improve metabolic health by modulating gut homeostasis. This study aims to investigate the effect of long-term consumption of BSG or bio-transformed BSG-containing biscuits on metabolic health in Singapore adults with metabolic impairments.

Methods: Thirty-one metabolic-impaired subjects were enrolled in this randomized controlled trial. Subjects consumed either 90 g/day control biscuits (C, n = 11), 30% wheat flour substituted autoclaved BSG- (ABSG, n = 10) or 30% wheat flour substituted bio-transformed BSG-containing biscuits (FBSG, n = 10) for 12 weeks. The concentration of fasting glucose, insulin, hemoglobin A1c and lipid-lipoprotein were assessed at pre- and post-intervention. Anthropometric, blood pressure and dietary intakes were also measured. Results are presented in change value mean ± standard error.

Results: FBSG consumption increased more daily dietary fiber intake than C and ABSG (FBSG vs. C vs. ABSG: 19 ± 4 g vs. -5 ± 2 g vs. 4 ± 3 g, P_interaction < 0.001). Moreover, high-density lipoprotein (HDL) cholesterol significantly increased in FBSG group after intervention (0.08 ± 0.03 mmol/L, P = 0.024). However, no significant difference was observed in other indicators.

Conclusions: FBSG consumption promotes daily dietary fiber intake and further improves blood lipoprotein profile.

Funding Sources: This study is supported by the Ministry of Education, Singapore.