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Obesity (Poster Session)

(P15-039-24) Associations of Dietary and Circulating Total Branched-Chain Amino Acids With Obesity Among Filipino Women

Sunday, June 30, 2024
11:45 AM – 12:45 PM CT
Location: Poster Board 38

    Presenting Author(s)

  • AO

    Akinkunmi Paul Okekunle, PhD

    Assistant Professor
    Seoul National University
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

    • Co-Author(s)

  • HL

    Heejin Lee, MS

    Graduate student
    Seoul National University
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

  • SP

    Sherlyn Mae P. Provido, PhD

    Graduate student
    Seoul National University
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

  • GC

    Grace H. Chung, PhD

    Seoul National University
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

  • SH

    Sangmo Hong, PhD

    Hanyang University Guri Hospital, Hanyang University College of Medicine
    Guri, Seoul-t'ukpyolsi, Republic of Korea

  • SY

    Sung Hoon Yu, PhD

    Hanyang University Guri Hospital, Hanyang University College of Medicine
    Guri, Seoul-t'ukpyolsi, Republic of Korea

  • CL

    Chang Beom Lee, PhD

    Hanyang University Guri Hospital, Hanyang University College of Medicine
    Guri, Seoul-t'ukpyolsi, Republic of Korea

  • JL

    Jung Eun Lee, ScD

    Associate Professor
    Seoul National University
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

Disclosure(s):
Akinkunmi Paul Okekunle, PhD: No relevant financial relationship(s) with ineligible companies to disclose.


Objectives: This study assessed the independent and joint relationships of dietary and circulating total branched-chain amino acids (tBCAA) with obesity among Filipino women in Korea.

Methods: A total of 540 Filipino women, out of which 170 were overweight/obese, were included in this study. Energy-adjusted dietary tBCAA intakes were evaluated using the 24-hour recalls, and serum tBCAA profiles were determined using high-throughput proton–nuclear magnetic resonance metabolomics in the Filipino women's diet and health study. Dietary and serum tBCAA were ranked by quartiles. Dietary and serum tBCAA were dichotomized by median ('low' - < median and 'high' - ≥median) and combined into four joint categories to examine the joint association. Overweight/obesity was a body mass index of≥ 25kg/m2. Multivariable-adjusted logistic regression was used to compute the odds ratio (OR)s and 95% confidence intervals (CI)s of obesity prevalence.

Results: Higher energy-adjusted dietary tBCAA intakes were inversely related to overweight/obesity prevalence, but higher serum tBCAA profiles were associated with higher overweight/obesity prevalence. The age-adjusted ORs (95% CIs) for subsequent quartiles of dietary tBCAA intakes were 1.00, 0.86 (0.52, 1.44), 0.73 (0.44, 1.23) and 0.61 (0.36, 1.03; P for trend < 0.05). For serum tBCAA levels, ORs (95% CIs) for subsequent quartiles compared to the first quartile were 2.65 (1.41, 4.70), 3.74 (2.02, 6.92), and 6.42 (3.50, 11.79; P for trend < 0.001). When we examined the joint association of dietary and circulating tBCAAs, ORs (95% CIs) for overweight/obesity prevalence were 2.14 (1.27, 3.60) for low dietary and high serum tBCAA, 0.53 (0.29, 0.98) for high dietary and low serum tBCAA and 2.03 (1.19, 3.48) for high dietary and high serum tBCAA, compared to low dietary and low serum tBCAA (P for interaction = 0.61). The multivariable-adjusted regression models revealed similar trends.

Conclusions: Higher dietary BCAA intake was modestly associated with obesity prevalence, but higher serum BCAA was associated with higher odds of obesity.

Funding Sources: Seoul National University Asia Center; National Research Foundation of Korea; the Hanmi Pharmaceutical Co., Ltd; Chong Kun Dang Pharm; Yuhan Corporation